Already in 1994, it was shown that colon adenocarcinoma cells enhanced the expression of major histocompatibility complex 1 (MHC-1) and intercellular adhesion molecule 1 (ICAM-1) upon butyrate exposure, which makes tumor cells more sensitive to cytotoxic lymphocytes-mediated killing (35). This evidence concerns the gene ICAM1 and colon adenocarcinoma.