HbAS variant has been associated with 50% and 80% reduced risks of developing uncomplicated and severe malaria (Williams, 2005b), HbAC and HbC variants have been associated with 30% and 93% reduced risks of developing mild and severe malaria, respectively (Modiano et al., 2001; Taylor, Parobek & Fairhurst, 2012; Agarwal et al., 2000; Travassos et al., 2015). This evidence concerns the gene KRT88P and malaria.