Glucose-6-phosphate dehydrogenase (G6PD) and β-chain of haemoglobin (HBB) deficiencies are more prevalent in malaria-endemic countries and are two of the essential loci conferring resistance to severe malaria in humans (Mackinnon et al., 2005; Grignard et al., 2019). The gene discussed is G6PD; the disease is malaria.