Over activation or inactivation of autophagy induced by some biomolecules will promote myocardial hypertrophy and pathological remodeling, and worsen the progression and condition of heart failure (104–106), such as overexpression of autophagy promoting protein Beclin-1 (106), the family of Toll like receptors 3 (TLR3) (94), METTL3 (64, 74), to name a few. The gene discussed is METTL3; the disease is heart failure.