RYR2 and heart failure: The overexpression of FTO can enhance myocardial contractility, improve cardiac function and delay the development of heart failure by demethylating contraction genes, such as, sarcoplasmic reticulum (SR) -Ca2+ ATPase 2a (SERCA2a), ryanodine 2 (RyR2), myosin heavy chain (MYH) 6/7, and increasing their protein expression level, and even reversing cardiac fibrosis and inducing angiogenesis in heart failure after myocardial infarction.