Compared with patients without any arrhythmia, patients with COVID-19 with arrhythmias showed more often need for oxygen therapy [21 patients (84.0%) vs. 40 patients (53.3%), p = 0.009], higher oxygen maximum flow [5.7 L/min ± 6.3 vs. 3.2 L/min ± 5.0, p = 0.047], higher CRP at admission [84.5 mg/L ± 44.2 vs. 62.3 mg/L ± 55.4, p = 0.037], longer QTc at admission [462.5 ms ± 46.5 vs. 444.6 ms ± 42.6, p = 0.042], and more extensive pulmonary involvement at CT severity score [13.2 ± 5.4 vs. 7.2 ± 5.1, p < 0.001]. This evidence concerns the gene CRP and COVID-19.