CSF2 and infection: In addition to the MelJuSo-Mav infection model, we also developed a Mav infection model using primary monocyte-derived human macrophages, differentiated into two diametrically opposed subsets, namely, GM-CSF-driven classically activated pro-inflammatory macrophages (M1), and M-CSF-driven alternatively activated anti-inflammatory macrophages (M2), which represent the two main phenotypes of human alveolar macrophages (Mitsi et al., 2018; Hu and Christman, 2019).