A2M and metabolic dysfunction-associated steatohepatitis: In conclusion, A2M, HA, TIMP1, PIIINP, type IV collagen, PRO-C3, and AKR1B10 are biomarkers that directly respond to fibrosis in NASH, but these biomarkers remain to be investigated in patients with other chronic liver diseases, and further validation is needed for their extension in the clinical setting.