Though a tendency toward a polarization into a MIL4/IL13‐like macrophage could be noted, the variance of changes in gene expression of related marker genes over time indicates not only the difficulty to distinguish between MIFNg/LPS and MIL4/IL13 macrophages, but also points at a phenotypic plasticity of macrophages dependent on time and contextual cues from surrounding tumor as well as TM cells (Fig. 6A). The gene discussed is IL13; the disease is neoplasm.