In conclusion, components of the ECM (collagen I, collagen IV, and fibronectin) favored a pro‐tumorigenic environment by decreasing the cisplatin sensitivity, as well as enhancing the migratory and adhesive capacity, thereby putatively allowing phenotypic plasticity in GCT cells, for example, by promoting the EMT (Fig. 6B). Here, FN1 is linked to granular cell tumor.