In agreement with previous data showing no significant differences in SIRT1 and SIRT6 expression in hASCs from subcutaneous AT depots of individuals with obesity (Mariani et al., 2016), we found no changes across the hASC groups; however, we found a significant decrease in SIRT1 and SIRT6 protein expression in the elderly and obese groups, underlining the important role of post‐transcriptional and post‐translational regulation of sirtuins (Houtkooper et al., 2012). Here, SIRT6 is linked to obesity disorder.