SIRT1 and obesity due to melanocortin 4 receptor deficiency: Sirtuins are key metabolic sensors involved in the pathophysiology of inflammatory‐related processes including aging and obesity (Vachharajani et al., 2016), and both obesity (Song et al., 2013) and aging (Khanh et al., 2018) have been associated with a reduction in SIRT1 activity in AT.