PAPPA2 and non-small cell lung carcinoma: Based on the TCGA database, findings in the TCGA‐NSCLC dataset showed that the PAPPA2‐Mut group had higher TMB (p < 0.001) and NAL (p < 0.001) levels than the PAPPA2‐WT group (Figure 4A,B), consistent in the TCGA‐SKCM dataset (TMB, p < 0.001; NAL, p = 0.048; Figure 4C,D).