A specific blockade of HBx‐expression via plasmid‐mediated targeting of intracellular anti‐HBx mAb production and genetic activation of B56γ would help target the p‐AKTThr308/Ser473‐MMP2/9 signalling axis to mediate the multipattern chemoprevention and intervention in HBx‐associated hepatocarcinogenesis and HBV‐related HCC. Here, MMP2 is linked to hepatocellular carcinoma.