Furthermore, our previous results have suggested that the produced intracellular anti‐HBx mAb could reduce the cancer stemness characteristics of liver cancer associated with HBx‐induced B‐cell lymphoma 2/adenovirus E1B interacting 19 kDa‐interacting protein 3‐like (BNIP3L)‐dependent mitophagy and glycolysis metabolism reprogramming in HCC cells.47 This evidence concerns the gene BNIP3L and hepatocellular carcinoma.