CLDN18 and neoplasm: Furthermore, in spatial organization analysis, we also observed higher effective scores for CD8+ T, CD8+LAG-3− T, CD8+PD-1− T, CD8+TIM-3− T, CD4+FoxP3− T, CD4+FoxP3−CTLA-4− T, and CD4+FoxP3−PD-L1− T cells in CLDN18.2-positive tumors compared with CLDN18.2-negative tumors, suggesting a higher possibility of tumor-immune cell interaction.