In sarcoidosis, serum ACE levels are known to be increased in 60% of patients29 and correlate with the granuloma burden as it is produced by epithelioid cells in granulomas.20, 30 However, serum ACE level was not associated with a prognostic predictive value in the literature31 and the authors also could not observe a significant difference between the two groups in the present study. This evidence concerns the gene ACE and Granuloma.