MAPT and Cognitive impairment: In previous studies, we found that anesthesia with 3% sevoflurane administered twice daily for three days could cause neurotoxicity and cognitive impairment in neonatal mice (starting sevoflurane anesthesia on postnatal day 6 [P6]) but not in adult mice (starting sevoflurane anesthesia on postnatal day 60 [P60]), implying that abnormal Tau phosphorylation in the developing brain could be a key cause of anesthesia‐induced cognitive impairment (Yang et al., 2020; Yu et al., 2020).