APOE and Alzheimer disease: The formation of Aβ plaques, Tau hyperphosphorylation, NFT formation, and the onset of neurodegeneration and cognitive impairment in patients with AD have been associated with specific neurotoxic ApoE fragments, such as an 18 kDa N‐terminal fragment (Munoz et al., 2019; Rohn et al., 2012; Wang et al., 2018).