Our previous work in a medaka fish osteoporosis model has shown that CXCL9‐CXCR3 signaling is required and sufficient for osteoclast progenitor recruitment to osteoporotic lesion sites.(14) Using live in vivo imaging, we demonstrated that osteoblast‐derived Cxcl9l, the CXCL9 ortholog in fish, functioned to attract Cxcr3.2‐positive macrophages to bone matrix. This evidence concerns the gene CXCL9 and osteoporosis.