PDE10A and colorectal carcinoma: To confirm the feasibility of using methylation of the LINC00473 promoter for the noninvasive early detection of CRC, we retrospectively analyzed an independent cohort of plasma cfDNA samples (Cohort 7) obtained either prior to a scheduled colonoscopy as part of standard CRC screening or prior to colonic surgery for primary tumors (Fig. 4E, F).