SPRY4 and gastric cancer: Intriguingly, it was proposed that SPRY4-IT1 was extremely reduced in GC cells resulting in proliferation, invasion, and metastasis in vitro and in xenograft vivo due to the Epithelial-mesenchymal transition attributed to a decrease of E-cadherin and increase of Vimentin mostly and SPRY4-IT1 promoter region was highly hypermethylated, which restricts its expression [73].