Furthermore, another research revealed that small integral membrane protein 10 like 2A (linc00086) expression was lower in GC tissues compared with normal tissues regulated by DNA methylation resulted from regulation of MeCP2(Methyl-CpG binding protein 2) via extracellular signal-regulated kinase 1/2 signaling pathways (ERK1/2), which, alike, is involved in cancer progression through binding methylated CpG islands [67]. This evidence concerns the gene MAPK3 and cancer.