Usually, lncRNAs act as regulators to affect the methylation of related genes, thereby affecting the signaling pathways responsible for tumorigenesis, for example, it has been indicated that lncRNA MAGI2-AS3 may act as a vital element in inhibiting the DNA methylation of the MAGI2 promoter region, thus upregulating the expression level of MAGI2 and blocking the AKT pathway as well as the Wnt signaling pathway in breast cancer [59]. Here, MAGI2 is linked to breast carcinoma.