Transcript levels of conventional melanocytic markers (e.g. SILV, MLANA, and TYR) which are known to be dominantly regulated by MITF4,51, and of MITF itself were significantly inversely correlated with DNA methylation in the cell lines and TCGA melanoma samples (Fig. 4a, Supplementary Data 6–8). The gene discussed is MITF; the disease is melanoma.