MITF and melanoma: Predominance of the MEL state was also observed in a single-cell RNA-Seq analysis of melanoma tumors in which 7 of 10 tumors at bulk level displayed an MITF-high (here MEL) phenotype, despite all tumors evaluable at the single-cell level (n = 7) showing admixed MITF-high and AXL-high (here MEL and MES, respectively) phenotype cells6.