THSD4 and cancer: The coordinated upregulation of TRPM1 and miR-211-5p in MEL samples was consistent with a shared transcriptional regulation, which in the case of miR-211-5p, reinforces MEL gene set expression due to miR targeting of several MES genes including EPHB2, THSD4 (thrombospondin type I domain containing 4), NUAK1 (cancer-promoting driver of EMT)55, KCNMA1 (cancer invasion and metastasis)56, and ZEB1 (a key driver of EMT-like processes in melanoma)7.