ZEB1 and melanoma: We confirmed miR-211-5p targeting of ZEB1 at both transcript and protein level and demonstrated knockdown of ZEB1 protein following transfection-mediated overexpression of miR-211-5p in melanoma cells with high endogenous levels of ZEB1 in vitro (Fig. 5d, e), supporting the validity of our approach to the identification of meaningful multi-modal regulatory relationships.