Compared with MEL and MES state samples, cluster 2 samples had significantly enriched expression of 78 genes, and decreased expression of 6 genes (Supplementary Data 2), with KEGG pathway enrichments (pooling all differentially expressed genes) for sphingolipid metabolism, axon guidance, JAK-STAT signaling pathway, VEGF signaling pathway, BCR signaling pathway, focal adhesion, apoptosis, pancreatic cancer, small cell lung cancer (all q = 0.061), and TCR signaling pathway (q = 0.085)(Supplementary Data 3). This evidence concerns the gene VEGFA and small cell lung carcinoma.