Our work is consistent both with previous studies that identified DNA-methylation signatures, which included viral response and interferon signaling that will predicted SARS-CoV-2 infection and clinical outcome27, and with genome-wide DNA methylation signatures associated with severe COVID-19 that highlight hypermethylation in IFN-related genes, hypomethylation in inflammatory genes and increased epigenetic age28. This evidence concerns the gene IFNA1 and COVID-19.