We found that one of 40 intra-chromosomal CompG2 genotypes comprised of rs483082 (APOC1) and rs429358 was adversely associated with AD risk independently of the ε4 allele at Bonferroni-adjusted significance PBε4 = 8.77E-04 (= 0.05/57). Here, APOC1 is linked to Alzheimer disease.