Our analysis showed that none of eight CompG2 genotypes bearing SNPs from the APOE locus attained Bonferroni-adjusted significance PBε2 = 2.08E-03 (= 0.05/24), although rs405509 minor allele was beneficially associated with AD, independently of ε2, at nominal significance P = 0.0238. Here, APOE is linked to Alzheimer disease.