In addition, several SNPs mapped to the JADE2, FRMD4A, DDX10, SDK2, ZFP64, TSHZ2, ZDHHC14, NEGR1, and SLC5A8 genes, in interaction with SNPs in the other non-APOE-locus genes, were associated with AD-related brain pathologies such as diffuse amyloid plaque, PHF-tau, and neurofibrillary tangles at P < 5E-08 [55]. This evidence concerns the gene SDK2 and Alzheimer disease.