In stage 1, we found that rs429358 was in LD with 801 SNPs (143 loci) at P < 5E-06 in the AD group (301 SNP in 73 loci, Table S6), the NAD group (351 SNP in 81 loci, Table S7), or both AD and NAD groups (149 SNP; all in the APOE locus, except 2 SNPs, Table S8). Here, APOE is linked to Alzheimer disease.