In stage 1, we found that 306 SNPs mapped to 27 loci were in LD with rs7412 at P < 5E-06 in the AD group (21 SNPs in 9 loci, Table S2), the NAD group (198 SNPs in 20 loci, Table S3), or both AD and NAD groups (87 SNPs, all in the APOE locus, Table S4). This evidence concerns the gene APOE and Alzheimer disease.