From a molecular point of view, a recent study conducted in mice highlights the ability of Pb to induce the formation of aggregates and the inclusion of TAR DNA-binding protein (TDP-43), one of the main phenomena that occur in motor neurons during the ALS [47], data that although preliminary offer a possible scenario on the etiopathogenesis of Pb at the molecular level. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.