We found that LGG SN induced, in both CRC cells, a significant increase of ALOX15A, ALOX15B, GPR32, ChemR23 and BLT1 mRNA levels (Fig. S5A) and a statistically significant decrease of proangiogenic mediator mRNA levels (VEGF‐C, VEGF‐D, Ang1 and CXCL1) (Fig. S5B) when compared to control (culture broth). This evidence concerns the gene CXCL1 and colorectal carcinoma.