ANXA1 and colorectal carcinoma: In order to verify the possibility that LGG and FPR1 could induce AnxA1 expression in CRC cells, we treated both HT29 and HCT116 cells with LGG SN (1 : 30 titration), fMLF (10−9 m) or the three SPMs [RvD1 (1 nm), LXB4 (1 nm) and LXA4 (1 nm)] for 12 h and verified the expression levels of AnxA1, a potent endogenous proresolving and immunomodulatory protein [5].