These data indicate that FPR1 is able to activate in CRC cells an inflammation resolution program, by promoting the induction of SPMs (RvD1, LXA4 and LXB4), SPM enzymes (ALOX5, ALOX15A and ALOX15B) and SPM receptors (GPR32, ChemR23 and BLT1). The gene discussed is ALOX5; the disease is colorectal carcinoma.