Additionally, if the carriers with WDR62 variants in the previous study really did not present CHD phenotype, it also may be the following reasons: (1) the penetrance of WDR62 variants varies in the heart and brain, which may be due to tissue‐specific mechanisms of dosage compensation53 and (2) WDR62 may be a genetic modifier which contributes to CHD with other gene variants.54 The gene discussed is WDR62; the disease is coronary artery disorder.