In addition to its well-proved antimicrobial capabilities, doxycycline inhibits phorbol-12-myristate-13-acetate-mediated matrix metalloproteinase 8 (MMP-8) and MMP-9 in human endothelial cells, reducing elastin degradation and MMP activity in a model of aneurysmal disease. Here, ELN is linked to Vascular dilatation.