Recently, Jindal et al. [160] constructed a core-shell nanofibre scaffold capable of mediating the transfection of the connexin-43 gene into Cx43-deficient breast cancer cells (MCF-7), followed by the controlled and sustained release of 4-PB (a histone deacetylase inhibitor), showing great anti-proliferative potential activity in vitro and huge therapeutic translation ability via the Cx-based improvement of anti-cancer potential. The gene discussed is GJA1; the disease is cancer.