Health benefits of MedDiet, with high consumption of extra virgin olive oil and nuts, have been repeatedly reproduced including its protective effects against the prevalence and progression of metabolic syndrome (MetS) [5], lower insulin resistance, arterial stiffness, blood pressure, serum lipids, and oxidative stress as well as lower sub-clinical atherosclerosis and cardiovascular disease (CVD) risk [6]. This evidence concerns the gene INS and metabolic syndrome.