In the Irish cohort, significant associations with higher CRC risks were observed for variants in two selenoprotein genes: rs5859 in SELENOF (dominant model OR = 1.54; 95% CI: 1.10, 2.15, p = 0.012; additive model OR = 1.49; 95% CI: 1.12, 1.98, p = 0.006) and rs2972994 in SELENOP (dominant model OR = 1.44; 95% CI: 1.01, 2.05, p = 0.044), with similar risk estimates for advanced colorectal neoplasia (i.e., tumors and adenomas combined). Here, SELENOS is linked to adenoma.