SELENOS and colorectal carcinoma: This association with selenoprotein variants and CRC risk is thought to be more apparent in areas of suboptimal Se availability; one possible explanation for these differences is that a higher intake of Se may counteract the decreased functional efficiency of selenoprotein synthesis (and possible subsequent modified CRC risk) caused by selenoprotein gene variants and the hierarchical regulation of selenoprotein biosynthesis [11,44].