For neoplasia stratification in the Irish cohort, several variants in selenoprotein and Se metabolism genes, i.e., rs5859-SELENOF, rs4659382-SELENON, rs2972994-SELENOP, and rs2275129-SEPHS1, were associated with an increased risk of advanced colorectal neoplasia, whereas SELENOS rs34713741 was associated with a decreased risk of advanced colorectal neoplasia. This evidence concerns the gene SEPHS1 and neoplasm.