Our findings indicate that the combined effect of LPL and CETP SNPs (rs327, rs3200218 and rs4783961) on obesity traits may be altered by SFA intake, where consumption of high amounts of SFA may increase the combined genetic risk of central obesity posed by LPL and CETP SNPs while a low intake of SFA may help to reduce this risk. This evidence concerns the gene CETP and obesity due to melanocortin 4 receptor deficiency.