Children with non-IgE mediated CMA or non-allergic milk-related symptoms present with GI symptoms (gastroesophageal reflux, vomiting, diarrhea, constipation, flatulence, blood and mucus in stools, colic, general symptoms, faltering growth) more frequently than those who do not suffer from CMA (65% vs. 42%; <0.001) [13]. This evidence concerns the gene IGHE and gastroesophageal reflux disease.