Figure 5B shows the stability of blood glucose levels during the clamp, with a reduction of the area under the curve after the CR protocol (p < 0.0001), reinforcing the improvement in insulin sensitivity (Figure 5C). Furthermore, there were differences in the homeostasis model of beta cell function (HOMA-Beta) and the homeostasis model of insulin resistance (HOMA-IR), with an increase of 473% (p = 0.0056) and a reduction of 61.1% (p = 0.0057), respectively (Figure 5D,E). The gene discussed is INS; the disease is Insulin resistance.