SLC22A8 and hyperuricemia: Among the secreted proteins, the dysfunction of ABCG2 (an ATP-driven efflux pump) has become one of the major factors in human hyperuricemia; OAT1 (encoded by SLC22A6)/OAT3 (encoded by SLC22A8) driven by α-KG leads to uric acid being secreted from the basolateral side of the cells to the renal tubular cells, and finally excreted in the urine.