Among the secreted proteins, the dysfunction of ABCG2 (an ATP-driven efflux pump) has become one of the major factors in human hyperuricemia; OAT1 (encoded by SLC22A6)/OAT3 (encoded by SLC22A8) driven by α-KG leads to uric acid being secreted from the basolateral side of the cells to the renal tubular cells, and finally excreted in the urine. This evidence concerns the gene SLC22A6 and hyperuricemia.