NLRP3 inflammasome complex has recently been implicated in IBD pathogenesis with a suspected pro-inflammatory effect; many susceptibility polymorphisms have been associated with the NLRP3 inflammasome IL-1b/18 axis, including NF-kB, CARD8, IL18, IL1b, and the NLRP3 gene itself [40]. Here, IL1B is linked to irritable bowel syndrome.