Nevertheless, processes such as inflammation (elevated IL-6 levels in BD patients), increased oxidative and nitrosative stress, epigenetic mechanisms, monoaminergic signalling, disturbance in neuronal and glial plasticity (including BDNF), HPA-dysregulation, and mitochondrial function are associated with the development of BD [6,12,114]. This evidence concerns the gene BDNF and Behcet disease.