Recently, Jędrzejewski et al. reported that protein-bound polysaccharides (PBP) from Coriolus versicolor can govern M1/M2 polarization, thus exhibiting anti-tumor activities in breast cancer progression, as revealed by an elevated level of IL-6, TNF-α (pro-inflammatory markers), and a decreased expression of IL-10, transforming growth factor-β (TGF-β), and arginase 1 (M2 markers) after PBP treatment [67]. This evidence concerns the gene TNF and neoplasm.