PLAU and cervical carcinoma: Phosphorylation of p38 MAPK is selectively and strongly depressed without altering the amount of protein in FIS-treated cells, while the phosphorylation of ERK1/2, JNK1/2 and AKT show no significant changes, indicating that FIS inhibits uPA expression and reduces migration and invasion of cervical cancer cells via inactivation of the p38 MAPK pathway.