SP7 and uremia: Since uremia and high serum P cause aortic miR-145 reductions [8,14] and miR-145 is implicated in the regulation of the expression of contractile markers [10,11] and directly targets the osterix gene in osteoblasts [32], one of the goals of this study was to evaluate whether vascular miR-145 reductions could provide a non-traditional predictor of VSMC osteogenic differentiation and vascular calcification.