When the variable creatinine (over/below the median) was introduced, both creatinine (p = 0.001) and obesity (p = 0.024) were independently related to sclerostin over or below the median, but when a multiple regression analysis between sclerostin (as the independent variable) and creatinine and BMI was performed, only BMI -but not creatinine- was independently related to sclerostin (beta = 0.26; p = 0.014). The gene discussed is SOST; the disease is obesity due to melanocortin 4 receptor deficiency.