Although controversy exists regarding the vascular effects of sclerostin [55], and although in this study the relationship between sclerostin and hypertension was displaced by creatinine, undoubtedly, more research exploring the behavior of sclerostin in cirrhotics, confirming its relation with obesity, and exploring its relationship with mortality and/or vascular events are necessary. This evidence concerns the gene SOST and obesity due to melanocortin 4 receptor deficiency.