There was an association between hypertension and obesity (χ2 = 4.73; p = 0.03), and also a relationship between hypertension and diabetes (χ2 = 5.90; p = 0.015), but no relationship between the BMI groups (normal, overweight, obese) and severity of liver disease (Childs A, B or C groups; χ2 = 1.01; p = 0.60); however, in order to disclose which of these variables were independently related with sclerostin levels, we classified sclerostin according to median values and performed a logistic regression analysis introducing the variables cirrhosis, obesity, hypertension and diabetes. Here, SOST is linked to obesity due to melanocortin 4 receptor deficiency.