Creatinine showed a trend to higher values among obese patients vs. overweight and normal individuals (KW = 6.72; p = 0.035), but not when patients with ascites were excluded (KW = 5.83; p = 0.054); moreover, logistic regression analysis showed that the only variable related to obesity was sclerostin (p = 0.023). The gene discussed is SOST; the disease is obesity due to melanocortin 4 receptor deficiency.