SOST and obesity due to melanocortin 4 receptor deficiency: Adding controversy, some authors have found an inverse relationship with obesity (i.e., lower values in obese patients [18]), in sharp contrast with the results of Stanik et al. (2019), who showed a direct relationship between sclerostin and obesity in a wide sample of individuals aged less than 18 years [19]; moreover, documented sex differences (higher values in men than in women), both during the growing period [20] and in adult cohorts [21,22] and age-related changes [23] may complicate the interpretation of these findings.