TAS1R2 and obesity due to melanocortin 4 receptor deficiency: However, our studies cannot rule out that the cell division of β-tanycytes: (i) responds to sexual dimorphism [14] since only male rats were used; (ii) precedes the inflammatory microenvironment fostered in the pre-diabetes and pre-obesity [51,55,56,57,58]; and/or (iii) is due to a glucose-sensing mechanism dependent on the sweet taste receptor Tas1r2, and not the glucose metabolism, that may likewise evoke transmissible increases in calcium signals between tanycytes [59].