SIRT1 and malignant colon neoplasm: Related to the anti-cancer potential of curcumin, there are some studies proving that the natural compound induces apoptosis in cancer cells [156,173]; experimental studies show that SIRT1 is overexpressed in colon cancer cells, compared to normal cells; knockdown of SIRT1 led to the decreased viability and migration of cancer cells as well as a decrease in tumor volume and growth rate.