Moreover, curcumin was proven to support the metabolic activity and muscle force gain in a mouse model of cancer-induced cachexia; this effect being correlated with an increase in SIRT1 activity [188]; results were similar in a mouse model of disuse muscle atrophy, curcumin stimulating the number of muscle cells and SIRT1 activity [189], and also in a study proving that muscle performance was improved by curcumin through a stimulation of SIRT1 activity [190]. The gene discussed is SIRT1; the disease is cancer.