SIRT1 and fatty liver disease: Additionally, in a model of nonalcoholic fatty liver disease, curcumin reduced inflammation and steatosis, through an increase in SOD1 and SIRT1 expression [182]; another experiment showed that dietary curcumin reduced hepatic steatosis and improved mitochondrial function via SIRT3 activity, in a hepatic steatosis model in postnatal overfed rats [183].