SIRT1 and acute kidney injury: In a mouse model of sepsis-induced acute kidney injury, tetrahydrocurcumin increased the survival rate, improved the kidney function and ameliorated the renal histological damage, reduced the inflammatory response (IL-1β, IL-6, and TNF-α), alleviated the oxidative stress (measured by MDA level, SOD, GSH, CAT, and GPx activities), and prevented cell apoptosis in renal tissues of septic mice through an increased expression of SIRT1, associated with reduced downstream molecules Ac-p65 and Ac-foxo1 [145].