DNMT1 and colorectal cancer: Chlorogenic acid has been reported: (1) to modulate the NF-κB signaling pathway in breast cancer models [61]; (2) to induce S-phase cell-cycle arrest and apoptosis in colorectal cancer models [62]; (3) to inhibit proliferation, invasion, and metastasis by downregulating DNMT1 protein expression in hepatic carcinoma models [63]; (4) and to inhibit cellular proliferation by targeting annexin A2 in lung cancer models [64], as an isolated phytonutrient.