Available therapies currently in use for the treatment and management of diabetes include insulin and several oral hypoglycemic agents such as metformin, sulfonylureas, α-glucosidase inhibitors, meglitinide analogues, thiazolidinediones, DPP-IV inhibitors, SGLT-2 inhibitors, and GLP-1 mimetics. The gene discussed is INS; the disease is diabetes mellitus.