In this study, the bis-malonamide derivative 19h, with Ki against fXa equal to 57 nM and AChE/BChE inhibition potency in the very low (single-digit) micromolar range, may be considered a hit compound for further optimization studies and ex vivo/in vivo pharmacological investigations in animal models of AD-like neurodegeneration syndromes. Here, ACHE is linked to Alzheimer disease.