TNF and heart disorder: Inflammation is a physiological immune response of the body to injury, characterized by fever, swelling, and pain, and is usually implicated in the pathogenesis of a variety of diseases including, asthma, heart disease, cancer, and diabetes [1] During the inflammatory process, large amounts of pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) are generated, mostly for the primary protection of the host [2,3].