APP and Alzheimer disease: In addition, the measurement of mRNA levels in APP/PS1 transgenic mice showed that the HDACI BG45 blocked the effect of HDACs, activated gene transcription, and upregulated the expression levels of the related genes (GRIK2, SCN3B, SYP, Grm2, and Grid2IP); moreover, BG45 prevented the decrease in GluR2 expression in the AD model and reduced the level of phosphorylated GluR2 (S880 site).