NFKB1 and inflammatory bowel disease: The etiology of IBD is still not clear, but it is usually admitted that it results from an intricate relationship within environmental, microbial, genetic, and immunogenic factors that activate in mucosal T- cell immune response, which prompts the release of inflammatory mediators such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), reduction of antioxidant enzymes of the colonic mucosa, loss of integrity of the mucosal barrier, anti-inflammatory cytokines and markers, cell infiltrations, and NF-κB activation, which cause apoptotic injuries in the colon [4,5].