The key role of PDEEs including ANXA8L1, CASTOR2, CYP4B1, GTF2H2C, PSMF1, and TNS4 in pathogenesis and metastasis of NSCLC were validated based on GEPIA (Figure S2), UCSC xena (Figure S3), The Human Protein Atlas (Figure S4), cBioPortal (Figure S5), UALCAN (Figures S6 and S7) and OncoLnc (Figure S8). The gene discussed is GTF2H2C; the disease is non-small cell lung carcinoma.