Moreover, six key PDEEs (ANXA8L1, CASTOR2, CYP4B1, GTF2H2C, PSMF1, and TNS4) were identified as potential markers to predict the prognosis of NSCLC and provide references for the treatment of metastatic NSCLC, which occupied the central position in the NSCLC metastasis-specific regulation network. This evidence concerns the gene ANXA8L1 and non-small cell lung carcinoma.