Moreover, six key PDEEs (ANXA8L1, CASTOR2, CYP4B1, GTF2H2C, PSMF1, and TNS4) were identified as potential markers to predict the prognosis of NSCLC and provide references for the treatment of metastatic NSCLC, which occupied the central position in the NSCLC metastasis-specific regulation network. The gene discussed is TNS4; the disease is non-small cell lung carcinoma.