INS and type 2 diabetes mellitus: The present therapeutic drugs used in the management of T2DM are sulfonylureas, biguanides, SGLT2 inhibitors, alpha-glucosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, GLP-1 receptor agonists, thiazolidinediones, amylin analogs, and insulin [13].