TFRC and nutritional disorder: A siderophore–iron complex is expected to enter the cell through simple diffusion (according to the low iron concentration inside the cells regarding anemia induced by iron deficiency) via the endocytosis of the transferrin receptor (TfR1) Siderocalin/Lipocalin 2/Neutrophil Gelatinase Associated Lipocalin, which is an innate immune system protein with bacteriostatic activity, or ATP-binding cassette (ABC) transporters, the energy-dependent efflux transporters.