CASP3 and cancer: Since activation and cleavage of caspase-3 is considered to be the key modulator in cell apoptosis [6], we used flow cytometry to explore the changes in caspase-3 activity in cancer cell lines following treatment with 75 or 100 μg/mL of AHE-Ea-K, AHE-Ea-K L, ATE-Ea-E or ATE-Ea-F for 48 h.