Many research groups have predicted the inhibitory effect of various classes of heterocyclic compounds on the other isoforms of aldose reductase that are involved in diabetes [19,20] and cardiac complications [21,22], i.e., ALR-1 and ALR-2, but none of them have been discussed against the selected targeted proteins, i.e., AKR1B1 and AKR1B10, which are specifically involved in colon cancer. This evidence concerns the gene AKR1B1 and diabetes mellitus.