On the other hand, a recently published work evaluated the ferroptosis induced by another system also based on Fe3O4 nanoparticles in combination with gene interference (DMP controlled CRISPR/Cas13a knockdown of two iron metabolic genes, FPN and LCN2) for cancer therapy [55], which confirms the versatility and multiple therapeutic strategies that can be followed by using rationally designed iron oxide nanoparticles. The gene discussed is LCN2; the disease is cancer.